치과 임플란트에서 골개조 관련인자의 발현에 관한 연구

류승희; 김방신; 정승곤; 한만승; 국민석; 옥승호; 오희균; 박홍주

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치과 임플란트에서 골개조 관련인자의 발현에 관한 연구
Expression of osteoclastogenesis related factors in dental implant patients

대한구강악안면외과학회지 2010년 36권 5호 p.386 ~ 391

류승희, 김방신, 정승곤, 한만승, 국민석, 옥승호, 오희균, 박홍주,

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류승희 ( Ryu Seong-Hee ) - 전남대학교 치의학전문대학원 구강악안면외과학교실
김방신 ( Kim Bang-Sin ) - 전남대학교 치의학전문대학원 구강악안면외과학교실
정승곤 ( Jung Seung-Gon ) - 전남대학교 치의학전문대학원 구강악안면외과학교실
한만승 ( Han Man-Seung ) - 전남대학교 치의학전문대학원 구강악안면외과학교실
국민석 ( Kook Min-Suk ) - 전남대학교 치의학전문대학원 구강악안면외과학교실
옥승호 ( Ohk Seung-Ho ) - 전남대학교 치의학전문대학원 구강미생물학교실
오희균 ( Oh Hee-Kyun ) - 전남대학교 치의학전문대학원 구강악안면외과학교실
박홍주 ( Park Hong-Ju ) - 전남대학교 치의학전문대학원 구강악안면외과학교실

KMID : 0355620100360050386

Abstract

Introduction: Bone resorption is a unique function of osteoclasts. Osteoclasts are a specialized macrophage polykaryon whose differentiation is regulated principally by macrophage colony-stimulating factors, receptor activator of nuclear factor κB ligand (RANK) ligand, osteoprotegerin (OPG), and interleukins (IL). Reflecting the integrin-mediated signals, osteoclasts develop a specialized cytoskeleton that allows it to establish an isolated micro-environment between itself and the bone, wherein matrix degradation occurs by a process involving proton transport. The levels of IL-1, IL-6, OPG, and prostaglandin E2 (PGE2) expression were evaluated to study the correlations between dental implant teeth and the adjacent teeth.

Materials and Methods: The exudate of the gingival crevice acquired from dental implants, adjacent teeth, opposite teeth and contralateral teeth of 24 patients.

Results:
1. The levels of IL-1, IL-6, OPG and PGE2 expression in dental implant teeth were higher than those of the contralateral teeth.
2. IL-1 revealed a higher expression level in the adjacent teeth than in dental implant teeth.
3. The dental implant teeth and adjacent teeth did not show a remarkable difference in the level of IL-1 expression.
4. All the other cytokines were strongly expressed in the dental implant compared to the adjacent teeth.

Conclusion: These results suggest that there might be close correlation between dental implant teeth and adjacent teeth in terms of the expressions of cytokines that affect the development and regulation of osteoclasts.